I am a postdoctoral scholar using animal models to understand how autophagy, a cellular stress pathway, in the tumor microenvironment contributes to solid tumor progression.
I work with Jay Debnath, MD the University of California, San Francisco, currently funded by the American Cancer Society and the Jean Perkins Foundation.
My overarching research interest is to dissect the mechanisms and functions of epithelial-stromal and tissue-tissue crosstalk in development and cancer progression.
I participate in the UCSF IRACDA scholar training program, which prepares scholars for a career in academia. This has included co-instructing a course San Francisco State University.
My PhD is from the lab of Michael T. Lewis, PhD at Baylor College of Medicine (Houston, TX). My thesis project defined the epithelial and stromal functions of hedgehog network genes in mammary gland development. I also initiated a collaboration elucidating novel functions of the Patched 1 protein in an immune cell type in fertility with Yi Athena Ren, PhD (Cornell University, formerly BCM) and JoAnne Richards, PhD at BCM.
Contact Info
teresa.monkkonen@ucsf.edu
tmonkkonen@sfsu.edu
teresa.monkkonen@gmail.com
@tmfiesta (Twitter)
LinkedIn
ResearchGate
OrcID
I work with Jay Debnath, MD the University of California, San Francisco, currently funded by the American Cancer Society and the Jean Perkins Foundation.
My overarching research interest is to dissect the mechanisms and functions of epithelial-stromal and tissue-tissue crosstalk in development and cancer progression.
I participate in the UCSF IRACDA scholar training program, which prepares scholars for a career in academia. This has included co-instructing a course San Francisco State University.
My PhD is from the lab of Michael T. Lewis, PhD at Baylor College of Medicine (Houston, TX). My thesis project defined the epithelial and stromal functions of hedgehog network genes in mammary gland development. I also initiated a collaboration elucidating novel functions of the Patched 1 protein in an immune cell type in fertility with Yi Athena Ren, PhD (Cornell University, formerly BCM) and JoAnne Richards, PhD at BCM.
Contact Info
teresa.monkkonen@ucsf.edu
tmonkkonen@sfsu.edu
teresa.monkkonen@gmail.com
@tmfiesta (Twitter)
ResearchGate
OrcID
Publications
1. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Fiordelisio Coll T, Richards JS. S100A4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight (2019). Link PMID: 31265437
2. Monkkonen T, Landua JD, Visbal AP, and Lewis MT (2017). Epithelial and Non-Epithelial Patched-1 (Ptch1) Play Opposing Roles to Regulate Proliferation and Morphogenesis of the Mouse Mammary Gland. Development (144):1317-1327. Link PMID: 28275010
3. Monkkonen T, and Debnath, J (2017). Inflammatory Signaling Cascades and Autophagy in Cancer. Autophagy. Link PMID: 28813180
4. Monkkonen T, and Lewis MT (2017). New Paradigms for the Hedgehog Signaling Network in Mammary Gland Development and Breast Cancer. BBA Reviews on Cancer. 1868: 315-322. Link PMID: 28624497
5. Zhang, Y, Oetting WS, Harvey SB, Stone MD, Monkkonen T, Matas AJ, Cosio FG, Nelsestuen GL (2009). Urinary Peptide Patterns in Native Kidneys and Kidney Allografts. Transplantation 87 (12): 1807-183. Link PMID: 19543057
6. Harvey SB, Zhang Y, Wilson-Grady J, Monkkonen T, Nelsestuen GL, Kasthuri RS, Verneris MR, Lund TC, Ely EW, Bernard GR, Zeisler H, Homoncik M, Jilma B, Swan T, Kellogg TA (2008) O-Glycoside Biomarker of Apolipoprotein C3: Responsiveness to Obesity, Bariatric Surgery, and Therapy with Metformin, to Chronic or Severe Liver Disease and to Mortality in Severe Sepsis and Graft vs Host Disease. J Proteome Res 8 (2):603–612. Link PMID: 19055479
In revision:
1. Rudnick JA, Mar F, Barnes JM, Goldsmith J, Monkkonen T, Rostker F, Starobinets H, Roy S, Weaver VM, Debnath J. Autophagy in stromal fibroblasts promotes mammary tumorigenesis and desmoplasia.
Research Projects and Mentors
8/2016- present: Jayanta Debnath, MD (Chair and Associate Professor)
Dept. of Pathology
University of California, San Francisco
I am investigating the role of autophagy in vascular development, tumorigenesis, and metastasis. I am also working on a project on autophagy in cancer-associated fibroblasts using a mammary tumor model.
2010-2016: Michael T. Lewis, PhD
Dept. of Molecular and Cellular Biology & Lester and Sue Smith Breast Center
Baylor College of Medicine, Houston, TX
I studied the effects of conditional ablation of Patched 1 in the mammary epithelium, and in stromal cell types with respect to virgin mammary gland development. I also collaborated with JoAnne Richards, PhD and Yi Athena Ren, PhD at BCM to define stromal functions of Patched 1 in ovarian development and ovulation.
Dissertation title: Epithelial, Stromal, and Systemic Functions of Patched 1 in Mammary Gland Development.
2007-2008: Gary L. Nelsestuen, PhD
Dept. of Biochemistry, University of Minnesota, St. Paul, MN
I applied proteomic techniques (MALDI-TOF) to interrogate changes to plasma and urine proteomes of patients with different metabolic diseases.
2006-2007: James A. McNew, PhD
Dept. of Biochemistry and Cell Biology, Rice University, Houston TX
I completed a senior honors thesis studying C. elegans SNARE proteins and vesicle fusion using reconstituted liposomes.
Dept. of Pathology
University of California, San Francisco
I am investigating the role of autophagy in vascular development, tumorigenesis, and metastasis. I am also working on a project on autophagy in cancer-associated fibroblasts using a mammary tumor model.
2010-2016: Michael T. Lewis, PhD
Dept. of Molecular and Cellular Biology & Lester and Sue Smith Breast Center
Baylor College of Medicine, Houston, TX
I studied the effects of conditional ablation of Patched 1 in the mammary epithelium, and in stromal cell types with respect to virgin mammary gland development. I also collaborated with JoAnne Richards, PhD and Yi Athena Ren, PhD at BCM to define stromal functions of Patched 1 in ovarian development and ovulation.
Dissertation title: Epithelial, Stromal, and Systemic Functions of Patched 1 in Mammary Gland Development.
2007-2008: Gary L. Nelsestuen, PhD
Dept. of Biochemistry, University of Minnesota, St. Paul, MN
I applied proteomic techniques (MALDI-TOF) to interrogate changes to plasma and urine proteomes of patients with different metabolic diseases.
2006-2007: James A. McNew, PhD
Dept. of Biochemistry and Cell Biology, Rice University, Houston TX
I completed a senior honors thesis studying C. elegans SNARE proteins and vesicle fusion using reconstituted liposomes.
